منابع مشابه
TOPping up ATR Activity
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1976
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1976.tb12346.x